The most common side effects of tirzepatide are gastrointestinal and may include nausea, vomiting, diarrhea, constipation, abdominal discomfort, indigestion, decreased appetite, and bloating. These effects may be more noticeable when treatment is first started or when the dose is increased.
Less common but potentially serious side effects can occur, including pancreatitis, gallbladder problems, severe gastrointestinal symptoms, dehydration, kidney problems, allergic reactions, and low blood sugar, particularly when used with certain diabetes medications.
Tirzepatide carries a warning regarding the potential risk of thyroid C-cell tumors and may not be appropriate for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Your healthcare provider should review your medical history before treatment.